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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Laboratoire de Biologie Cellulaire, Université Paris-Val de Marne, Créteil, France.

Int J Biochem. 1993 Apr;25(4):479-82. doi: 10.1016/0020-711x(93)90653-v.

Most of proteins which are rapidly degraded inside eukaryotic cells have been found to contain amino acid sequences (PEST sequences) enriched in proline, acidic residues (glutamic acid and/or aspartic acid) and hydrophilic residues (serine and threonine) (Rogers et al. (1986) Science 234, 364-368). 2. This correlation was tested on nuclear proteins and a close relationship was found between nuclear protein stability and the presence of PEST regions. 3. Nuclear proteins with structural functions which can be considered as stable components of cell nuclei generally lack PEST sequences. 4. In contrast, regulatory nuclear factors which have specific and transient functions generally possess at least one PEST sequence.

人们发现，大多数在真核细胞内迅速降解的蛋白质都含有富含脯氨酸、酸性残基（谷氨酸和/或天冬氨酸）以及亲水性残基（丝氨酸和苏氨酸）的氨基酸序列（PEST序列）（罗杰斯等人，《科学》，1986年，第234卷，第364 - 368页）。2. 针对核蛋白对这种相关性进行了测试，结果发现核蛋白稳定性与PEST区域的存在之间存在密切关系。3. 具有结构功能、可被视为细胞核稳定成分的核蛋白通常缺乏PEST序列。4. 相比之下，具有特定和短暂功能的调节性核因子通常至少拥有一个PEST序列。

Laboratoire de Biologie Cellulaire, Université Paris-Val de Marne, Créteil, France.

Int J Biochem. 1993 Apr;25(4):479-82. doi: 10.1016/0020-711x(93)90653-v.

Most of proteins which are rapidly degraded inside eukaryotic cells have been found to contain amino acid sequences (PEST sequences) enriched in proline, acidic residues (glutamic acid and/or aspartic acid) and hydrophilic residues (serine and threonine) (Rogers et al. (1986) Science 234, 364-368). 2. This correlation was tested on nuclear proteins and a close relationship was found between nuclear protein stability and the presence of PEST regions. 3. Nuclear proteins with structural functions which can be considered as stable components of cell nuclei generally lack PEST sequences. 4. In contrast, regulatory nuclear factors which have specific and transient functions generally possess at least one PEST sequence.

人们发现，大多数在真核细胞内迅速降解的蛋白质都含有富含脯氨酸、酸性残基（谷氨酸和/或天冬氨酸）以及亲水性残基（丝氨酸和苏氨酸）的氨基酸序列（PEST序列）（罗杰斯等人，《科学》，1986年，第234卷，第364 - 368页）。2. 针对核蛋白对这种相关性进行了测试，结果发现核蛋白稳定性与PEST区域的存在之间存在密切关系。3. 具有结构功能、可被视为细胞核稳定成分的核蛋白通常缺乏PEST序列。4. 相比之下，具有特定和短暂功能的调节性核因子通常至少拥有一个PEST序列。