Hamers F P, Pette C, Neijt J P, Gispen W H
Department of Medical Pharmacology, Rudolf Magnus Institute, Medical Faculty Utrecht University, Netherlands.
Eur J Pharmacol. 1993 Mar 16;233(1):177-8. doi: 10.1016/0014-2999(93)90367-q.
Taxol is a novel and promising oncolytic agent the use of which is hampered by its neurotoxicity. We now describe a taxol-induced neuropathy in rats and its prevention by the adrenocorticotropic hormone-(4-9) (ACTH-(4-9)) analog, ORG 2766. A decrease in sensory nerve conduction velocity was seen in taxol-treated rats, both with daily injections of small amounts (6 mg/kg per week) and with weekly injections of higher amounts (9 mg/kg per week) of taxol. Concomitant administration of ORG 2766 completely prevented the occurrence of a neuropathy.
紫杉醇是一种新型且有前景的溶瘤剂，但其神经毒性阻碍了它的应用。我们现在描述一种在大鼠中由紫杉醇引起的神经病变以及促肾上腺皮质激素-（4-9）（ACTH-（4-9））类似物ORG 2766对其的预防作用。在接受紫杉醇治疗的大鼠中，无论是每日注射少量（每周6毫克/千克）还是每周注射大量（每周9毫克/千克）紫杉醇，均可观察到感觉神经传导速度下降。同时给予ORG 2766可完全预防神经病变的发生。
