Org.2766可保护大鼠免受顺铂诱导的神经毒性。
Org.2766 protects from cisplatin-induced neurotoxicity in rats.
作者信息
de Koning P, Neijt J P, Jennekens F G, Gispen W H
出版信息
Exp Neurol. 1987 Sep;97(3):746-50. doi: 10.1016/0014-4886(87)90132-4.
PMID:3040462
Abstract
One of the side-effects of the cytotoxic drug, cisplatin, is its neurotoxicity. In rats this neurotoxicity can be measured as a slowing of the H-reflex-related sensory nerve conduction velocity. Concurrent treatment with Org.2766 (an ACTH4-9 analog) prevents this neurotoxic side effect while leaving the antitumor activity of cisplatin unaffected.
摘要
细胞毒性药物顺铂的副作用之一是其神经毒性。在大鼠中，这种神经毒性可以通过H反射相关感觉神经传导速度的减慢来衡量。同时用Org.2766（一种促肾上腺皮质激素4-9类似物）进行治疗可预防这种神经毒性副作用，而顺铂的抗肿瘤活性不受影响。
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