Sporel-Ozakat R E, Edwards P M, Van der Hoop R G, Gispen W H
Bogazici University, Faculty of Arts and Sciences, Department of Biology, Istanbul, Turkey.
Eur J Pharmacol. 1990 Sep 21;186(2-3):181-7. doi: 10.1016/0014-2999(90)90432-6.
Org 2766 is one of a series of melanocortins (ACTH and related peptides) that exert trophic influences on the central and peripheral nervous system of the rat. We used acrylamide neuropathy in rats as an experimental model of peripheral neuropathies of the dying-back type in order to assess the potential therapeutic efficacy of Org 2766 in this type of nerve damage. The peptide reversed the delayed persistent deficit in sensory conduction velocity without preventing the initial loss of motor coordination. The recovery of apparently normal coordination was unaffected by the peptide, but resistance to a second toxic challenge suggested that recovery was more complete in the peptide-treated rats. The finding that Org 2766 improved the quality of the repair following acrylamide neuropathy, together with previous studies showing beneficial effects in neuropathies caused by cisplatin or diabetes and after mechanical trauma, strongly suggests that Org 2766 may be beneficial in the treatment of various conditions in which the nervous system has sustained damage.
Org 2766是一系列促黑素（促肾上腺皮质激素及相关肽）之一，对大鼠的中枢和外周神经系统具有营养作用。我们将大鼠丙烯酰胺神经病作为轴索性周围神经病的实验模型，以评估Org 2766在这类神经损伤中的潜在治疗效果。该肽逆转了感觉传导速度延迟的持续性缺陷，但未能预防运动协调性的最初丧失。明显正常的协调性恢复不受该肽的影响，但对第二次毒性攻击的抵抗力表明，肽处理组大鼠的恢复更为完全。Org 2766改善了丙烯酰胺神经病后的修复质量，以及先前研究显示其对顺铂或糖尿病所致神经病和机械创伤后具有有益作用，强烈提示Org 2766可能对治疗神经系统遭受损伤的各种病症有益。
