Montironi R, Galluzzi C M, Diamanti L, Giannulis I, Scarpelli M, De Nictolis M
Institute of Morbid Anatomy and Histopathology, School of Medicine, University of Ancona, Torrette di Ancona, Italy.
Anticancer Res. 1993 Jan-Feb;13(1):129-32.
Expression and location of Proliferating Cell Nuclear Antigen in epithelial nuclei were assessed in invasive adenocarcinoma of the prostate gland. The PCNA-positive nuclei showed homogeneous or granular types of immunostaining or a mixture of both, and a gradation in the intensity of staining. Nuclei with homogeneous pattern appeared darker brown than the lighter granular and mixed patterns. Darker nuclei were quite frequently noted, mainly among the epithelial cells adjacent to the stroma. For the marginal zone of invasive adenocarcinoma, the mean proportion of PCNA-stained nuclei in the small acinar pattern was somewhat similar to that in the large acinar pattern, i.e., 8.66% and 9.06%, respectively. In contrast, the mean values in the cribriform pattern were greater than in the small and large acinar patterns, and decreased from the nuclei in the basal position, or adjacent to the stroma, toward the lumen: 14.40% in the basal position, 11.84% in the intermediate and 9.26% in the lumenal. In the solid/trabecular pattern, the proportions of PCNA-positive nuclei were higher than in all the other patterns: 17.60% in the cell layer adjacent to the stroma and 13.88% in the other layers. The trend of value changes in the central zone of the tumour was similar to that obtained in the marginal zone. However, the proportions were lower and the differences statistically significant. This might indicate that the proliferation state is higher in the marginal zone and that the tumour grows eccentrically rather than centrally.
在前列腺浸润性腺癌中评估增殖细胞核抗原（PCNA）在上皮细胞核中的表达及定位。PCNA阳性细胞核呈现均匀型或颗粒型免疫染色或两者混合，且染色强度有梯度变化。呈现均匀模式的细胞核比浅颗粒型和混合型模式的细胞核颜色更深，呈深褐色。深色细胞核相当常见，主要见于与基质相邻的上皮细胞中。对于浸润性腺癌的边缘区，小腺泡模式中PCNA染色细胞核的平均比例与大腺泡模式中的比例 somewhat 相似，分别为8.66%和9.06%。相比之下，筛状模式中的平均值大于小腺泡和大腺泡模式，且从基底位置或与基质相邻的细胞核向管腔方向降低：基底位置为14.40%，中间位置为11.84%，管腔位置为9.26%。在实体/小梁模式中，PCNA阳性细胞核的比例高于所有其他模式：与基质相邻的细胞层中为17.60%，其他层中为13.88%。肿瘤中央区的数值变化趋势与边缘区相似。然而，比例较低且差异具有统计学意义。这可能表明边缘区的增殖状态较高，且肿瘤呈偏心生长而非向中心生长。 （注：“somewhat”此处翻译为“有点， somewhat”，可能需要结合更准确的语境进一步优化表述 ）
