抗生育药物棉酚可使大鼠肝线粒体释放钙。

The antifertility agent, gossypol, releases calcium from rat liver mitochondria.

Martínez F, Milán R, Espinosa-García T, Pardo J P

Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, D.F.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1993 Jan;104(1):165-9. doi: 10.1016/0742-8413(93)90129-9.

Abstract

The effect of gossypol in the presence of K+ or Ca2+, or both, was studied on respiration, ATPase activity, and Ca2+ transport of rat liver mitochondria. 2. The uncoupled respiration induced by gossypol was inhibited by Ca2+. 3. This inhibition was lowered by the presence of Mg2+. ATPase activity was stimulated when gossypol and Ca2+ were in the incubation medium, in a Ca(2+)-dose related fashion. 4. Mitochondrial Ca2+ was released by gossypol, an effect associated with the membrane fluidity. 5. The results suggest that gossypol modifies the mitochondrial concentration of Ca2+.

摘要

研究了棉酚在有钾离子或钙离子或两者同时存在的情况下对大鼠肝线粒体呼吸作用、ATP酶活性及钙离子转运的影响。2. 棉酚诱导的解偶联呼吸作用受到钙离子的抑制。3. 镁离子的存在可降低这种抑制作用。当棉酚和钙离子存在于孵育介质中时，ATP酶活性以与钙离子剂量相关的方式受到刺激。4. 棉酚可释放线粒体钙离子，这一效应与膜流动性有关。5. 结果表明棉酚可改变线粒体钙离子浓度。