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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Gill J E, Kerins G M, Langton S D, MacNicoll A D

Central Science Laboratory, Ministry of Agriculture, Fisheries and Food, Slough, Berkshire, U.K.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1993 Jan;104(1):29-36. doi: 10.1016/0742-8413(93)90106-u.

A new test for identifying levels of difenacoum resistance in the Norway rat is described, based upon the differential physiological response to difenacoum administration. 2. This test is based on changes in blood clotting activity over 4 days, following administration of the rodenticide difenacoum in conjunction with menadione (vitamin K3). 3. The anticoagulant effect is reduced only in rats that are resistant or tolerant to difenacoum. 4. This test procedure is quicker than traditional feeding tests, and identifies the degree of resistance in both laboratory and wild rats that have difenacoum resistance genes.

本文描述了一种基于对溴敌隆给药的不同生理反应来鉴定挪威大鼠对溴敌隆抗性水平的新测试方法。2. 该测试基于在与甲萘醌（维生素K3）联合施用杀鼠剂溴敌隆后4天内血液凝固活性的变化。3. 只有对溴敌隆具有抗性或耐受性的大鼠，其抗凝血作用才会降低。4. 该测试程序比传统的喂食测试更快，并且能鉴定出具有溴敌隆抗性基因的实验室大鼠和野生大鼠的抗性程度。

Gill J E, Kerins G M, Langton S D, MacNicoll A D

Central Science Laboratory, Ministry of Agriculture, Fisheries and Food, Slough, Berkshire, U.K.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1993 Jan;104(1):29-36. doi: 10.1016/0742-8413(93)90106-u.

A new test for identifying levels of difenacoum resistance in the Norway rat is described, based upon the differential physiological response to difenacoum administration. 2. This test is based on changes in blood clotting activity over 4 days, following administration of the rodenticide difenacoum in conjunction with menadione (vitamin K3). 3. The anticoagulant effect is reduced only in rats that are resistant or tolerant to difenacoum. 4. This test procedure is quicker than traditional feeding tests, and identifies the degree of resistance in both laboratory and wild rats that have difenacoum resistance genes.

本文描述了一种基于对溴敌隆给药的不同生理反应来鉴定挪威大鼠对溴敌隆抗性水平的新测试方法。2. 该测试基于在与甲萘醌（维生素K3）联合施用杀鼠剂溴敌隆后4天内血液凝固活性的变化。3. 只有对溴敌隆具有抗性或耐受性的大鼠，其抗凝血作用才会降低。4. 该测试程序比传统的喂食测试更快，并且能鉴定出具有溴敌隆抗性基因的实验室大鼠和野生大鼠的抗性程度。