全氟碳浓缩乳剂在大鼠淋巴组织中的摄取情况。
Uptake of concentrated perfluorocarbon emulsions into rat lymphoid tissues.
作者信息
Bentley P K, Johnson O L, Washington C, Lowe K C
机构信息
Department of Life Science, University of Nottingham, University Park, UK.
出版信息
J Pharm Pharmacol. 1993 Mar;45(3):182-5. doi: 10.1111/j.2042-7158.1993.tb05529.x.
The effects of injecting (10-30 mL kg-1) either perfluorodecalin (FDC) emulsions of increasing phase fraction (20-60% w/v) or the commercial formulation, Fluosol, on lymphoid tissues have been studied for up to 7 days in male rats. Tissue weights increased by up to 123% (P < 0.05) in proportion with quantity of perfluorochemical (PFC) injected, with spleen responses consistently greater than those of the liver. PFC droplets recovered from these tissues at 72 h after injection of 30% (w/v) FDC emulsion (10 mL kg-1) had mean diameters in the 1-10 microns range, with those from the spleen being larger than those from the liver. Recovered droplet diameters were considerably greater than freshly-prepared emulsion mean particle sizes (0.21-0.25 microns). These results suggest that coalescence of emulsion droplets following accumulation in lymphoid tissue is a pre-requisite for the eventual excretion of PFC vapour through the lungs.
在雄性大鼠中，研究了注射递增相分数（20 - 60% w/v）的全氟萘烷（FDC）乳剂（10 - 30 mL kg-1）或市售制剂氟索对淋巴组织的影响，长达7天。组织重量随全氟化合物（PFC）注射量的增加而增加，最高可达123%（P < 0.05），脾脏的反应始终大于肝脏。在注射30%（w/v）FDC乳剂（10 mL kg-1）72小时后，从这些组织中回收的PFC液滴平均直径在1 - 10微米范围内，脾脏中的液滴大于肝脏中的液滴。回收的液滴直径明显大于新制备的乳剂平均粒径（0.21 - 0.25微米）。这些结果表明，乳剂液滴在淋巴组织中积累后聚结是PFC蒸汽最终通过肺部排出的先决条件。
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