Aozasa K, Ohsawa M, Horiuchi K, Saeki K, Katayama S, Matsuzuka F, Yamamura T
Department of Pathology, Nara Medical University, Kashihara, Japan.
Mod Pathol. 1993 Mar;6(2):121-4.
Occurrence of monocytoid B-lymphocytes (MBL) in extranodal organs in various inflammatory diseases was examined. MBL were present in 5 (11.4%) of 44 patients with Graves' disease, 11 (36.7%) of 30 with Hashimoto's thyroiditis, 1 (8.3%) of 12 with lymphoid follicular hyperplasia (LFH) of stomach, 1 (10%) of 10 with cutaneous LFH, and 0 of 5 with LFH of lung. The MBL presented as irregularly shaped nodular collections of cells, directly surrounding secondary follicles. Immunohistochemistry revealed a B-cell nature of these cells which expressed the following antigens; CD3-, CD 15-, CD45RA+, CD45Ro-, CDw 75+, CD74+, Mx-PanB+, MB-1+, EMA-. There were no immunoglobulin light chain restriction among infiltrating lymphoid cells. MBL in 2 of 18 cases showed positive reaction for CD43. The patients with MBL were older than those without MBL in each organ site, though the difference was not statistically significant. These findings showed that the MBL could appear in nonlymphoid organs affected by long-standing inflammation. High frequency of the appearance of the MBL in Hashimoto's thyroiditis suggest that MBL proliferation correlates with an impaired immune status.
研究了各类炎症性疾病的结外器官中单核样B淋巴细胞（MBL）的出现情况。在44例格雷夫斯病患者中，5例（11.4%）存在MBL；在30例桥本甲状腺炎患者中，11例（36.7%）存在MBL；在12例胃淋巴滤泡增生（LFH）患者中，1例（8.3%）存在MBL；在10例皮肤LFH患者中，1例（10%）存在MBL；在5例肺LFH患者中，无MBL出现。MBL表现为围绕次级滤泡的形状不规则的结节状细胞聚集。免疫组织化学显示这些细胞具有B细胞性质，表达以下抗原：CD3阴性、CD15阴性、CD45RA阳性、CD45Ro阴性、CDw75阳性、CD74阳性、Mx - PanB阳性、MB - 1阳性、EMA阴性。浸润的淋巴细胞中无免疫球蛋白轻链限制。18例中有2例的MBL对CD43呈阳性反应。每个器官部位有MBL的患者比无MBL的患者年龄大，尽管差异无统计学意义。这些发现表明MBL可出现在受长期炎症影响的非淋巴器官中。桥本甲状腺炎中MBL出现的高频率表明MBL增殖与免疫状态受损相关。
