Levitt M D
Minneapolis Veterans Administration Medical Center, MN 55417.
Aliment Pharmacol Ther. 1993 Apr;7(2):131-8. doi: 10.1111/j.1365-2036.1993.tb00081.x.
It has been proposed that an appreciable fraction of ingested ethanol is metabolized in the gastric mucosa and that inhibition of this metabolism by H2-receptor antagonists produces clinically important increases in blood ethanol. This paper reviews available data concerning gastric metabolism of ethanol and the influence of H2-antagonists on ethanol metabolism. It concludes that very little, if any, metabolism of ethanol is likely to occur in the gastric mucosa, and the interaction between H2-antagonists and ethanol is clinically insignificant.
有人提出，摄入的乙醇有相当一部分在胃黏膜中代谢，并且H2受体拮抗剂对这种代谢的抑制会导致血液中乙醇含量出现具有临床意义的升高。本文综述了关于乙醇胃代谢以及H2拮抗剂对乙醇代谢影响的现有数据。结论是，乙醇在胃黏膜中的代谢即使有也微乎其微，并且H2拮抗剂与乙醇之间的相互作用在临床上无足轻重。
