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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Miller R R, Yates J W, Geer B W

Department of Biology, Knox College, Galesburg, IL 61401.

Comp Biochem Physiol Comp Physiol. 1993 Apr;104(4):837-44. doi: 10.1016/0300-9629(93)90163-x.

Low to moderate concentrations of dietary ethanol (200 mM to 600 mM) significantly increased the level of phosphatidylethanolamine (PE), while phosphatidylcholine (PC) levels decreased in third instar larvae. This was seen in both ethanol tolerant and intolerant strains of Drosophila melanogaster, indicating that the reduction of PC is not associated with a high level of ethanol tolerance. 2. The phospholipid changes were not ethanol-specific. Larvae fed ethanol, n-butanol, isopropanol, methanol, and n-propanol exhibited similar changes. 3. At 200 mM concentrations, dietary ethanol acted as a competitive inhibitor for the larval uptake of dietary choline. At higher concentrations, dietary ethanol acted as a noncompetitive inhibitor. This ethanol-induced inhibition of dietary choline uptake can only partially explain the ethanol-induced reductions in larval PC.

低至中等浓度的膳食乙醇（200 mM至600 mM）显著提高了磷脂酰乙醇胺（PE）的水平，而三龄幼虫中的磷脂酰胆碱（PC）水平则下降。在黑腹果蝇的乙醇耐受和不耐受菌株中均观察到这种情况，这表明PC的减少与高水平的乙醇耐受性无关。2. 磷脂变化并非乙醇特有的。喂食乙醇、正丁醇、异丙醇、甲醇和正丙醇的幼虫表现出类似的变化。3. 在200 mM浓度下，膳食乙醇作为幼虫摄取膳食胆碱的竞争性抑制剂。在更高浓度下，膳食乙醇作为非竞争性抑制剂。这种乙醇诱导的膳食胆碱摄取抑制只能部分解释乙醇诱导的幼虫PC减少。

Miller R R, Yates J W, Geer B W

Department of Biology, Knox College, Galesburg, IL 61401.

Comp Biochem Physiol Comp Physiol. 1993 Apr;104(4):837-44. doi: 10.1016/0300-9629(93)90163-x.

Low to moderate concentrations of dietary ethanol (200 mM to 600 mM) significantly increased the level of phosphatidylethanolamine (PE), while phosphatidylcholine (PC) levels decreased in third instar larvae. This was seen in both ethanol tolerant and intolerant strains of Drosophila melanogaster, indicating that the reduction of PC is not associated with a high level of ethanol tolerance. 2. The phospholipid changes were not ethanol-specific. Larvae fed ethanol, n-butanol, isopropanol, methanol, and n-propanol exhibited similar changes. 3. At 200 mM concentrations, dietary ethanol acted as a competitive inhibitor for the larval uptake of dietary choline. At higher concentrations, dietary ethanol acted as a noncompetitive inhibitor. This ethanol-induced inhibition of dietary choline uptake can only partially explain the ethanol-induced reductions in larval PC.

低至中等浓度的膳食乙醇（200 mM至600 mM）显著提高了磷脂酰乙醇胺（PE）的水平，而三龄幼虫中的磷脂酰胆碱（PC）水平则下降。在黑腹果蝇的乙醇耐受和不耐受菌株中均观察到这种情况，这表明PC的减少与高水平的乙醇耐受性无关。2. 磷脂变化并非乙醇特有的。喂食乙醇、正丁醇、异丙醇、甲醇和正丙醇的幼虫表现出类似的变化。3. 在200 mM浓度下，膳食乙醇作为幼虫摄取膳食胆碱的竞争性抑制剂。在更高浓度下，膳食乙醇作为非竞争性抑制剂。这种乙醇诱导的膳食胆碱摄取抑制只能部分解释乙醇诱导的幼虫PC减少。