Maxwell L P, Jain A
W V Med J. 1993 Apr;89(4):148-51.
Ten to 15 years ago, the thrust of research in the treatment of congestive heart failure centered around finding new inotropic agents. While initially useful, these agents given chronically actually accelerated left ventricular failure and were associated with excess mortality. Recently, it has been learned that altering the body's response to heart failure is more beneficial compared to attempts to stimulate left ventricular inotropic function. Such altering of the neurohumoral responses to heart failure has been associated with improvements in both morbidity and mortality.
10到15年前，充血性心力衰竭治疗研究的重点是寻找新的正性肌力药物。虽然这些药物最初有一定作用，但长期使用实际上加速了左心室衰竭，并与额外的死亡率相关。最近，人们认识到，与试图刺激左心室的正性肌力功能相比，改变机体对心力衰竭的反应更有益。这种对心力衰竭神经体液反应的改变与发病率和死亡率的改善都有关。
