Forster D J, Rao N A, Hill R A, Nguyen Q H, Baerveldt G
Department of Ophthalmology, University of Southern California, Los Angeles.
Ophthalmology. 1993 May;100(5):613-8. doi: 10.1016/s0161-6420(93)31604-0.
The Vogt-Koyanagi-Harada syndrome is a bilateral panuveitis associated with neurologic and dermatologic manifestations.
The authors reviewed the charts of all patients with Vogt-Koyanagi-Harada syndrome seen at their institution over the past decade to determine the incidence of glaucoma, as well as the results of medical and surgical therapy for glaucoma, in this group of patients.
Of 42 patients diagnosed with Vogt-Koyanagi-Harada syndrome, evidence of glaucoma requiring either medical or surgical intervention occurred in 16 patients (38.1%). Of these, nine (56.3%) had open-angle glaucoma and seven (43.7%) had angle-closure secondary to pupillary block. In 5 (31.3%) of the 16 patients, medical therapy alone was sufficient to control intraocular pressure. Eleven patients (68.7%) required surgical intervention, consisting of laser iridotomy, surgical iridectomy, trabeculectomy with or without 5-fluorouracil, and/or Molteno implantation.
The relative success of each of these procedures in this group of patients is discussed. Glaucoma is a common complication in the Vogt-Koyanagi-Harada syndrome, and one that is often difficult to control.
伏格特-小柳-原田综合征是一种伴有神经和皮肤表现的双侧全葡萄膜炎。
作者回顾了过去十年间在其机构就诊的所有伏格特-小柳-原田综合征患者的病历，以确定该组患者中青光眼的发病率以及青光眼的药物和手术治疗结果。
在42例被诊断为伏格特-小柳-原田综合征的患者中，有16例（38.1%）出现了需要药物或手术干预的青光眼证据。其中，9例（56.3%）为开角型青光眼，7例（43.7%）为瞳孔阻滞继发的闭角型青光眼。在这16例患者中的5例（31.3%），单纯药物治疗足以控制眼压。11例患者（68.7%）需要手术干预，包括激光虹膜切开术、手术虹膜切除术、有或无5-氟尿嘧啶的小梁切除术和/或莫尔顿植入术。
讨论了这些手术在该组患者中的相对成功率。青光眼是伏格特-小柳-原田综合征的常见并发症，且往往难以控制。
