邻苯二甲酸二（2-乙基己基）酯在蚯蚓（赤子爱胜蚓）体内的代谢
The metabolism of di(2-ethylhexyl)phthalate in the earthworm Lumbricus terrestris.
作者信息
Albro P W, Corbett J T, Schroeder J L
机构信息
Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
出版信息
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1993 Feb;104(2):335-44. doi: 10.1016/0742-8413(93)90045-m.
PMID:8098688
Abstract
- Earthworms can hydrolyze di-(2-ethylhexyl) phthalate (DEHP) to mono-2-ethylhexyl phthalate (MEHP) and phthalic acid (PA). 2. They apparently cannot produce the side-chain-oxidized derivatives of MEHP that constitute the major DEHP metabolites in higher animals. 3. With the assistance of intestinal bacterial Pseudomonas, the worm-derived PA is degraded through protocatechuic and beta-carboxymuconic acids to CO2. 4. There is an indication of a second pathway for degradation of PA leading through benzoic acid.
摘要
- 蚯蚓可将邻苯二甲酸二（2-乙基己基）酯（DEHP）水解为邻苯二甲酸单-2-乙基己酯（MEHP）和邻苯二甲酸（PA）。2. 它们显然无法产生构成高等动物体内主要DEHP代谢物的MEHP侧链氧化衍生物。3. 在肠道细菌假单胞菌的协助下，蚯蚓产生的PA通过原儿茶酸和β-羧基粘康酸降解为二氧化碳。4. 有迹象表明PA存在通过苯甲酸的第二条降解途径。
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