Skurygin V P, Davidov V V
Vopr Med Khim. 1993 Jan-Feb;39(1):22-5.
The systems regulating the levels of Ca(2+)-Mg2+, Ca(2+)-ATPase and potential-dependent absorption of Ca2+ as well as content of cyclic nucleotides, beta-adrenoreceptors, activities of adenylate-, guanylate cyclases and phosphodiesterase were studied in the synaptosomes of rat brain cortex in evolving myocardial infarction. In addition, reverse absorption of noradrenaline, dopamine and serotonin was studied. In one of the animal groups myocardial infarction was simulated after stress. The myocardial infarction, affecting the systems of Ca2+ regulation, caused an increase in reverse absorption of dopamine and serotonin simultaneously with accumulation of lactate in the synaptosomes. In myocardial infarction developed after stress adenylate cyclase was activated, reverse absorption of dopamine was decreased and the content of lactate tended to decrease as compared with the infarction formed without stress effects.
研究了在进展性心肌梗死大鼠大脑皮层突触体中调节Ca(2+)-Mg2+、Ca(2+)-ATP酶水平以及Ca2+的电位依赖性吸收以及环核苷酸含量、β-肾上腺素能受体、腺苷酸环化酶、鸟苷酸环化酶和磷酸二酯酶活性的系统。此外，还研究了去甲肾上腺素、多巴胺和5-羟色胺的逆向摄取。在其中一组动物中，应激后模拟心肌梗死。影响Ca2+调节系统的心肌梗死，导致多巴胺和5-羟色胺逆向摄取增加，同时突触体中乳酸积累。与无应激影响形成的梗死相比，应激后发生的心肌梗死中腺苷酸环化酶被激活，多巴胺逆向摄取减少，乳酸含量趋于降低。
