Yu C Q, Wang D Z, Wang Z Q
Changhai Hospital, Second Military Medical College.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1993 Jan;13(1):7-9, 3.
In order to explore the correlation between endometriosis and beta-Endorphin, Dynorphin, the beta-Endorphin and Dynorphin levels in menstrual blood of normal women and patients with endometriosis, and the pituitary-hypothalamic beta-Endorphin and Dynorphin levels in animal models were determined. The results indicated: (1) The plasma beta-Endorphin and Dynorphin levels in patients with endometriosis were significantly lower than those in normal women (P < 0.05); the plasma beta-Endorphin levels in patients with endometriosis were significantly higher after treatment of Endometriosis Pill No. 2 (P < 0.05). (2) The pituitary and hypothalamic beta-Endorphin levels in untreated group were significantly higher than those in the control group (P < 0.05); the hypothalamic beta-Endorphin in treated group were obviously higher than those in untreated group (108.35 +/- 35.38 and 66.63 +/- 14.29 respectively). The above-mentioned results presented evidence that the low beta-Endorphin and Dynorphin levels in endometriotic patients play a role in dysmenorrhea; the effect of Endometriosis Pill No. 2 in relieving dysmenorrhea was realized through an increase of plasma and hypothalamic beta-Endorphin levels. (3) The Pituitary and hypothalamic beta-Endorphin levels were significantly different between the animal models of endometriosis and normal control groups.
为探讨子宫内膜异位症与β-内啡肽、强啡肽的相关性，测定了正常女性和子宫内膜异位症患者月经血中β-内啡肽和强啡肽水平，以及动物模型中垂体-下丘脑β-内啡肽和强啡肽水平。结果表明：（1）子宫内膜异位症患者血浆β-内啡肽和强啡肽水平显著低于正常女性（P<0.05）；服用二号子宫内膜异位症丸治疗后，子宫内膜异位症患者血浆β-内啡肽水平显著升高（P<0.05）。（2）未治疗组垂体和下丘脑β-内啡肽水平显著高于对照组（P<0.05）；治疗组下丘脑β-内啡肽水平明显高于未治疗组（分别为108.35±35.38和66.63±14.29）。上述结果表明，子宫内膜异位症患者β-内啡肽和强啡肽水平降低在痛经中起作用；二号子宫内膜异位症丸缓解痛经的作用是通过提高血浆和下丘脑β-内啡肽水平实现的。（3）子宫内膜异位症动物模型与正常对照组垂体和下丘脑β-内啡肽水平存在显著差异。
