Aravich P F, Rieg T S, Lauterio T J, Doerries L E
Department of Anatomy and Neurobiology, Eastern Virginia Medical School, Norfolk 23501.
Brain Res. 1993 Sep 17;622(1-2):1-8. doi: 10.1016/0006-8993(93)90794-n.
Exercise and the endogenous opioids have been linked to anorexia nervosa. This investigation determined the effects of the weight-loss syndrome induced by voluntary exercise (22.5 h/day) in food-restricted rats (1.5 h/day food access) on the endogenous opioids. The animals were tested under resting-fed and 2-deoxy-D-glucose (2DG) stimulated conditions. Weight-matched, freely fed exercised and ad libitum fed unexercised groups served as controls. Specific opioid abnormalities were found in the syndrome. These included a basal elevation in plasma beta-endorphin, which was abnormally suppressed by 2DG, and 2DG-induced elevations in arcuate hypothalamic beta-endorphin content and supraoptic hypothalamic dynorphin-A content. None of these changes occurred in controls. Finally, it was found that short-term moderate exercise itself chronically reduced adenohypophysial beta-endorphin content and elevated supraoptic dynorphin-A content. The relationship of the syndrome's hyperendorphinism to the hypothalamo-pituitary-adrenal axis and the auto-addiction hypothesis of anorexia nervosa was considered, as was the significance of the supraoptic dynorphin-A abnormality to the hypothalamo-neurohypophysial system. The differential sensitivity of the supraoptic dynorphin-A system compared to the arcuate hypothalamic beta-endorphin system to moderate exercise was also discussed.
运动与内源性阿片类物质已被认为与神经性厌食症有关。本研究确定了在食物受限的大鼠（每天1.5小时进食时间）中，由自愿运动（每天22.5小时）诱导的体重减轻综合征对内源性阿片类物质的影响。在静息喂食和2-脱氧-D-葡萄糖（2DG）刺激条件下对动物进行测试。体重匹配、自由进食的运动组和随意进食的非运动组作为对照。在该综合征中发现了特定的阿片类物质异常。这些异常包括血浆β-内啡肽的基础水平升高，而2DG可异常抑制该升高，以及2DG诱导的弓状下丘脑β-内啡肽含量和视上核下丘脑强啡肽A含量升高。对照组未出现这些变化。最后，发现短期适度运动本身会长期降低腺垂体β-内啡肽含量，并升高视上核强啡肽A含量。研究考虑了该综合征的高内啡肽血症与下丘脑-垂体-肾上腺轴的关系以及神经性厌食症的自我成瘾假说，还探讨了视上核强啡肽A异常对下丘脑-神经垂体系统的意义。此外，还讨论了视上核强啡肽A系统与弓状下丘脑β-内啡肽系统相比对适度运动的不同敏感性。
