Niechaj A, Wójcik G, Lupa K
Arch Int Physiol Biochim. 1978 May;86(2):385-91. doi: 10.3109/13813457809069913.
Correlations between the resting blood pressure and magnitude of depressor responses evoked by graded stimulation of the aortic nerve, were studied in rabbits anaesthetized with urethane. The strength of stimulation ranged from 1 to 10 times the threshold, and activated the myelinated afferents. The frequency of stimulation was 5 and 50 cycles/sec. At lower frequency of stimulation the correlations become significant when the intensity of stimulation is 3 times the threshold and they increase at the highest strengths of stimulation. Correlation coefficients calculated for responses obtained at the frequency of 50 cycles/sec are significant in 8 out of 9 intensities of stimulation. With increase in the strength of stimulation they increase, attain their maximum at twice the threshold and decrease at the largest used stimulus strengths. The changes in the values of the correlation coefficients are not paralleled by alterations in the mean size of depressor responses. Since all correlation coefficients are positive, it is inferred that the depressor responses produced by stimulation of the aortic nerve follow WILDER's "law of initial value". The conformity with this rule is the better the higher the values of the correlation coefficients. The strength of relationship between the resting blood pressure and the size of depressor responses is considered to reflect the efficiency of the homeostatic circulatory mechanism.
在氨基甲酸乙酯麻醉的家兔中，研究了静息血压与主动脉神经分级刺激诱发的降压反应幅度之间的相关性。刺激强度范围为阈值的1至10倍，激活有髓传入神经。刺激频率为5和50次/秒。在较低刺激频率下，当刺激强度为阈值的3倍时，相关性变得显著，并且在最高刺激强度时增加。在50次/秒频率下获得的反应计算的相关系数在9种刺激强度中的8种中是显著的。随着刺激强度的增加，它们增加，在阈值的两倍时达到最大值，并在最大使用刺激强度时减小。相关系数值的变化与降压反应平均大小的改变并不平行。由于所有相关系数均为正，因此推断主动脉神经刺激产生的降压反应遵循怀尔德的“初始值定律”。相关系数值越高，与该规则的符合程度越好。静息血压与降压反应大小之间的关系强度被认为反映了稳态循环机制的效率。
