Lupa K, Wójcik G, Niechaj A
Arch Int Physiol Biochim. 1978 Oct;86(4):809-12. doi: 10.3109/13813457809069533.
The effect of changes in frequency of the conditioning tetanus on the magnitude of the testing depressor response was studied in rabbits anaesthetized with urethane. Conditioning and testing stimulations were applied to the same aortic nerve. The duration of the conditioning tetani was set at 3 and 60 sec and the interval between stimulations amounted to 40 and 120 sec. At the testing interval of 40 sec the increase in frequency both of short and long conditioning tetani reduces the magnitude of the testing response which attains a minimum at frequency of about 30 cycles/sec. Conditioning stimulations of higher frequency are gradually less effective and cause the testing response to increase. Similar depression is observed at the testing interval of 120 sec but only following long-lasting conditioning tetanus. Short conditioning trains at the testing interval of 120 sec facilitate the testing response. The frequency of the conditioning stimulation which produces the greatest reduction of the depressor response indicates the range of control exerted by the conditioning tetanus over the testing blood pressure effect. The size of this control is determined by the lowest level of depression and the highest value of facilitation of the testing response.
在用乌拉坦麻醉的家兔中，研究了条件性强直刺激频率的变化对测试性降压反应幅度的影响。条件性刺激和测试性刺激施加于同一条主动脉神经。条件性强直刺激的持续时间设定为3秒和60秒，刺激间隔为40秒和120秒。在40秒的测试间隔时，短时间和长时间的条件性强直刺激频率增加均会降低测试反应的幅度，在约30次/秒的频率时达到最小值。更高频率的条件性刺激效果逐渐减弱，并导致测试反应增加。在120秒的测试间隔时也观察到类似的抑制，但仅在长时间的条件性强直刺激之后出现。在120秒的测试间隔时，短时间的条件性强直刺激会促进测试反应。产生最大降压反应降低的条件性刺激频率表明了条件性强直对测试血压效应的控制范围。这种控制的大小由测试反应抑制的最低水平和促进的最高值决定。
