Philip P E
Acta Haematol. 1975;54(3):188-91. doi: 10.1159/000208071.
A female patient with chronic myeloid leukemia in acute phase was found to have trisomy 11 in her bone marrow cells. The contemporary existence of different clones suggests the following clonal evolution: 46,XX leads to 46,XX,Ph' leads to 47,XX,Ph', +11 leads to 48,XX,Ph', +11, +Ph'. It is suggested, that the cytogenetic events leading to trisomy C in advanced cases of chronic myeloid leukemia are of a different character than those which often results in trisomy C in other myeloid disorders.
一名处于急性期的慢性髓性白血病女性患者被发现其骨髓细胞中存在11号染色体三体。不同克隆的同时存在提示了以下克隆进化过程：46,XX导致46,XX,Ph'，进而导致47,XX,Ph', +11，再导致48,XX,Ph', +11, +Ph'。有人提出，在慢性髓性白血病晚期病例中导致C组染色体三体的细胞遗传学事件与在其他髓系疾病中常导致C组染色体三体的事件具有不同的性质。
