Brandt L, Mitelman F, Sjögren U
Acta Haematol. 1975;54(5):280-3. doi: 10.1159/000208086.
Using Giemsa banding technique, the bone marrow chromosomes were studied in 9 patients with acute myeloid leukaemia (AML). Four patients had 100% normal diploid cells and 5 had 100% abnormal cells: 28-92% of the mitoses were found in erythroid cells. The percentage of erythroblasts with megaloblastoid changes was abnormally high. It was not increased in the cases with chromosomal abnormalities. These findings indicate that chromosomal aberrations are not prerequisites for the development of megaloblasts in AML. Furthermore, abnormalities in the DNA synthesis bringing about the megaloblastoid changes may occur without influencing karyotype.
运用吉姆萨显带技术，对9例急性髓系白血病（AML）患者的骨髓染色体进行了研究。4例患者有100%正常二倍体细胞，5例有100%异常细胞：28% - 92%的有丝分裂见于红系细胞。具有巨幼样变的幼红细胞百分比异常高。在染色体异常的病例中该百分比并未升高。这些发现表明，染色体畸变并非AML中巨幼细胞形成的先决条件。此外，导致巨幼样变的DNA合成异常可能在不影响核型的情况下发生。
