两名选择性血清IgA缺乏症兄弟体内的抗IgA抗体

Anti-IgA antibodies in two brothers with selective serum IgA deficiency.

作者信息

Invernizzi F, Balestrieri G, Consogno G, Riboldi P S, Tincani A

出版信息

Acta Haematol. 1975;54(5):312-20. doi: 10.1159/000208091.

DOI:10.1159/000208091

Abstract

A selective serum IgA deficiency with anti-IgA antibodies at high titer were found in a patient who suffered severe transfusion reactions. The same abnormalities were detected in his brother, a 72-year-old-man in good general condition. Anti-IgA antibodies were found in the IgG fraction and were directed against alpha-chains. A deficiency of isoagglutinins and an absence of heteroagglutinins in the propositus' serum could be shown.

摘要

在一名发生严重输血反应的患者中发现了选择性血清IgA缺乏伴高滴度抗IgA抗体。在他72岁、一般状况良好的哥哥身上也检测到了同样的异常。抗IgA抗体存在于IgG组分中，且针对α链。先证者血清中同种凝集素缺乏且异种凝集素缺失得以证实。