Gilhus N E, Hammarström L
Department of Neurology, University of Bergen, Norway.
Int J Immunopharmacol. 1991;13(2-3):185-8. doi: 10.1016/0192-0561(91)90097-q.
Sera from 22 phenytoin-treated epileptic patients with a serum IgA less than 0.30 g/l were examined for anti-IgA antibodies using an ELISA. Only one patient had a complete IgA deficiency. Anti-IgA antibodies of restricted specificity were detected in serum from two of the patients. Their serum IgA concentrations were 0.03 and 0.27 g/l. The serum concentrations of IgM, IgG and the IgG subclasses were normal in both these patients. The frequency of this type of anti-IgA antibody is not higher in epileptic patients with a low serum IgA than in healthy controls, and class-specific anti-IgA antibodies are not a pathogenetic factor in the IgA deficiency occurring in epilepsy.
对22例血清IgA低于0.30g/l的苯妥英治疗的癫痫患者血清，采用酶联免疫吸附测定法检测抗IgA抗体。仅1例患者存在完全性IgA缺乏。在2例患者血清中检测到特异性受限的抗IgA抗体。他们的血清IgA浓度分别为0.03和0.27g/l。这2例患者的血清IgM、IgG及IgG亚类浓度均正常。血清IgA水平低的癫痫患者中这类抗IgA抗体的发生率并不高于健康对照，且类别特异性抗IgA抗体并非癫痫患者发生IgA缺乏的致病因素。
