Antinori A, Maiuro G, Pallavicini F, Valente F, Ventura G, Marasca G, Murri R, Pizzigallo E, Camilli G, Tamburrini E
Clinica delle Malattie Infettive, Università Cattolica S. Cuore, Roma, Italy.
Eur J Epidemiol. 1993 Mar;9(2):183-9. doi: 10.1007/BF00158789.
Fifty-five episodes of Pneumocystis carinii pneumonia (PCP) in AIDS patients were evaluated to assess clinical and laboratory risk factors predicting the probability of surviving the acute episode of PCP and the long-term survival after PCP. Age > 45 yrs, PaO2 < 50 mmHg, AaPO2 > 50 mmHg, and LDH > 800 IU/L correlated strongly with early mortality; patients who needed mechanical ventilation had a significantly lower PaO2 and serum albumin, and higher AaPO2 and LDH compared to the patients who did not. Neither age nor PaO2, AaPO2, LDH, albumin, days from onset, time for recovery, CD4+ cell count correlated with long-term survival of AIDS patients with PCP. Informations obtained at initial presentation of PCP may predict early outcome and influence therapeutic approach, improving chances for survival.
对55例艾滋病患者的卡氏肺孢子虫肺炎（PCP）发作情况进行了评估，以评估预测PCP急性发作存活概率及PCP后长期生存的临床和实验室危险因素。年龄>45岁、动脉血氧分压（PaO2）<50 mmHg、肺泡-动脉血氧分压差（AaPO2）>50 mmHg和乳酸脱氢酶（LDH）>800 IU/L与早期死亡率密切相关；与不需要机械通气的患者相比，需要机械通气的患者PaO2和血清白蛋白显著降低，AaPO2和LDH更高。年龄、PaO2、AaPO2、LDH、白蛋白、起病天数、恢复时间、CD4+细胞计数均与PCP艾滋病患者的长期生存无关。PCP初次出现时获得的信息可预测早期预后并影响治疗方法，从而提高生存机会。
