De Potter C R, Foschini M P, Schelfhout A M, Schroeter C A, Eusebi V
N. Goormaghtigh Instituut voor Pathologische Anatomie, Universitair Ziekenhuis Gent, Belgium.
Virchows Arch A Pathol Anat Histopathol. 1993;422(5):375-80. doi: 10.1007/BF01605456.
The expression of neu protein in 26 cases of clinging carcinoma (CC) of the breast was investigated. A distinction is made between two types of CC: one with pleomorphic nuclei (PN) and the other with monomorphic nuclei (MN). The PN type of CC overexpresses the neu protein in almost all cases (85.7%), its cells generally exhibit abundant cytoplasm and intraluminal necrosis is frequently observed. The MN type of CC does not overexpress the neu protein, exhibits bland cytological features and shows no necrosis. It is suggested that CC with PN is related to comedo-type carcinoma, while CC with MN is the forerunner of cribriform carcinoma in situ.
研究了26例乳腺浸润性癌（CC）中neu蛋白的表达情况。CC分为两种类型：一种是核多形性（PN）型，另一种是核单形性（MN）型。PN型CC在几乎所有病例（85.7%）中均过度表达neu蛋白，其细胞通常表现为丰富的细胞质，且经常观察到管腔内坏死。MN型CC不表达neu蛋白，细胞学特征平淡，无坏死表现。提示PN型CC与粉刺型癌有关，而MN型CC是原位筛状癌的前身。
