Oxford J S, Frezza P, Race E
London Hospital Medical College, Whitechapel, UK.
Vaccine. 1993;11(6):612-4. doi: 10.1016/0264-410x(93)90303-f.
The major topics covered at this conference included the relevance of the SIV-macaque model for HIV vaccine development, an evaluation of the methods for producing inactivated vaccine, and the possibility of developing attenuated retrovirus vaccines. The possibility that there might be a Graft Versus Host Disease component in human AIDS was discussed, and also the recent discovery that the 'original antigenic sin' phenomenon encountered in influenza vaccines may also be seen in AIDS. It was concluded that results from animal models were encouraging in the quest for an HIV-1 vaccine.
SIV-猕猴模型对HIV疫苗研发的相关性、对生产灭活疫苗方法的评估以及开发减毒逆转录病毒疫苗的可能性。会议讨论了人类艾滋病中可能存在移植物抗宿主病成分的可能性，以及最近发现的流感疫苗中出现的“原始抗原罪”现象在艾滋病中也可能出现的情况。得出的结论是，在寻求HIV-1疫苗的过程中，动物模型的结果令人鼓舞。
