淋巴细胞对乙肝表面抗原的反应。肝炎和印度儿童肝硬化的研究结果。
Lymphocyte response to hepatitis B surface antigen. Findings in hepatitis and Indian childhood cirrhosis.
作者信息
Chandra R K
出版信息
Arch Dis Child. 1975 Jul;50(7):559-61. doi: 10.1136/adc.50.7.559.
Abstract
The lymphocyte delayed hypersensitivity response to phytohaemagglutinin (PHA) and hepatitis B antigen (HBsAG) was evaluated by two in vitro tests-leucocyte migration inhibition and DNA synthesis. Patients convalescing from HBsAG-positive hepatits showed the presence of a state of cell-mediated immune responsiveness to the antigen. In Indian childhood cirrhosis, there was a failure of response to HBsAG and a slight but significant depression of reaction to PHA. It is suggested that the lack of immune reactivity to HBsAG, perhaps determined genetically, may be a significant factor in the evolution of cirrhosis in Indian children.
摘要
通过白细胞游走抑制和DNA合成这两项体外试验，对淋巴细胞对植物血凝素（PHA）和乙肝抗原（HBsAG）的迟发型超敏反应进行了评估。从HBsAG阳性肝炎中康复的患者表现出对该抗原的细胞介导免疫反应状态。在印度儿童肝硬化中，对HBsAG无反应，对PHA的反应有轻微但显著的降低。有人提出，对HBsAG缺乏免疫反应性，可能由基因决定，可能是印度儿童肝硬化发展中的一个重要因素。
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本文引用的文献
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Indian childhood cirrhosis.印度儿童肝硬化
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Hepatitis-associated antigen and depressed cellular immunity in Indian childhood cirrhosis.印度儿童肝硬化中的肝炎相关抗原与细胞免疫抑制
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Gastric acid secretion with maximal augmented histamine stimulation in Indian childhood cirrhosis.印度儿童肝硬化中组胺最大刺激下的胃酸分泌
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A leucocyte migration technique for in vitro detection of cellular (delayed type) hypersensitivity in man.一种用于体外检测人体细胞（迟发型）超敏反应的白细胞迁移技术。
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