Kulander L, Nisbeth U, Danielsson B G, Eriksson O
Department of Clinical Chemistry, University Hospital, Uppsala, Sweden.
J Hosp Infect. 1993 May;24(1):29-37. doi: 10.1016/0195-6701(93)90087-g.
Endotoxin exposure during haemodialysis may cause acute and chronic adverse reactions. In order to estimate the risk to the patient, samples of dialysis fluid from 39 of the 45 dialysis units in Sweden were analysed by the chromogenic Limulus amoebocyte lysate assay. Higher levels were obtained after the usual weekend shutdowns. The length of the tubing delivering the reverse osmosis water seemed to influence the extent of contamination. Fifty-nine percent of the units showed low mean endotoxin levels (i.e. mean concentration below the recommended limit in Sweden: < 25 ng l-1), while 18% of units had high levels (mean concentration > 100 ng l-1).
血液透析过程中接触内毒素可能会引发急性和慢性不良反应。为评估对患者的风险，采用显色鲎试剂法对瑞典45个透析单元中39个单元的透析液样本进行了分析。通常在周末停机后检测到的内毒素水平更高。输送反渗透水的管道长度似乎会影响污染程度。59%的单元内毒素平均水平较低（即平均浓度低于瑞典推荐限值：<25 ng l-1），而18%的单元内毒素水平较高（平均浓度>100 ng l-1）。
