Robinson D I, Lertsumitkul S, Billson F A, Robinson L P
Sydney Eye Hospital, Sir John Young Crescent, Woolloomooloo, NSW.
Aust N Z J Ophthalmol. 1993 May;21(2):79-85. doi: 10.1111/j.1442-9071.1993.tb00758.x.
A retrospective study of 179 eyes in 127 patients who underwent trabeculectomy at Sydney Eye Hospital under the supervision of two surgeons between 1977 and 1982 was carried out. Survival analysis by life table method shows cumulative two, five, and 10 year success rates to be 78%, 70%, and 67% respectively, with mean duration of intraocular pressure control (IOP < 21 mmHg) being 88 months. Antiglaucoma medication improved the long-term survival significantly (Hazard Ratio of 0.49 and P = 0.01) so that when the definition for failure is taken as IOP > 20 mmHg while using medication, the two, five and 10 year success rates were 89%, 87% and 86% respectively. A rise in average intraocular pressure is seen between two weeks and three months after trabeculectomy. The improvement in long-term success rate with use of topical steroids was suggestive (Hazard Ratio of 0.69) but not conclusive (P = 0.21). No difference was found in survival comparing fornix versus limbal based flap technique.
对1977年至1982年间在悉尼眼科医院由两位外科医生监督下接受小梁切除术的127例患者的179只眼睛进行了回顾性研究。采用生命表法进行生存分析，结果显示2年、5年和10年的累积成功率分别为78%、70%和67%，眼压控制（眼压<21 mmHg）的平均持续时间为88个月。抗青光眼药物显著提高了长期生存率（风险比为0.49，P = 0.01），因此当将使用药物时眼压>20 mmHg定义为失败时，2年、5年和10年的成功率分别为89%、87%和86%。小梁切除术后两周至三个月期间可见平均眼压升高。使用局部类固醇激素可提高长期成功率，这一点具有提示性（风险比为0.69），但尚无定论（P = 0.21）。在穹窿部与角膜缘为基底的瓣技术的生存比较中未发现差异。
