内源性Mtv编码的超抗原并非小鼠艾滋病发展所必需。
Endogenous Mtv-encoded superantigens are not required for development of murine AIDS.
作者信息
McCarty T C, Chattopadhyay S K, Scherer M T, Fredrickson T N, Hartley J W, Morse H C
机构信息
Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA.
出版信息
J Virol. 1996 Nov;70(11):8148-50. doi: 10.1128/JVI.70.11.8148-8150.1996.
Abstract
Immune activation in murine AIDS (MAIDS) has been suggested to involve a superantigen (SAG). The possibility that SAGs encoded by mammary tumor virus (MTV) might be the source of stimulation was studied by using Mtv mice. Mtv- mice developed typical MAIDS, excluding a requirement for Mtv-encoded SAGs in the pathogenesis of this disorder.
摘要
有人提出，鼠类获得性免疫缺陷综合征（MAIDS）中的免疫激活涉及一种超抗原（SAG）。通过使用Mtv小鼠，研究了乳腺肿瘤病毒（MTV）编码的SAGs可能作为刺激源的可能性。Mtv基因敲除小鼠患上了典型的MAIDS，排除了该疾病发病机制中对Mtv编码的SAGs的需求。
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