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内源性Mtv编码的超抗原并非小鼠艾滋病发展所必需。

Endogenous Mtv-encoded superantigens are not required for development of murine AIDS.

作者信息

McCarty T C, Chattopadhyay S K, Scherer M T, Fredrickson T N, Hartley J W, Morse H C

机构信息

Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA.

出版信息

J Virol. 1996 Nov;70(11):8148-50. doi: 10.1128/JVI.70.11.8148-8150.1996.

DOI:10.1128/JVI.70.11.8148-8150.1996
PMID:8892943
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC190892/
Abstract

Immune activation in murine AIDS (MAIDS) has been suggested to involve a superantigen (SAG). The possibility that SAGs encoded by mammary tumor virus (MTV) might be the source of stimulation was studied by using Mtv mice. Mtv- mice developed typical MAIDS, excluding a requirement for Mtv-encoded SAGs in the pathogenesis of this disorder.

摘要

有人提出，鼠类获得性免疫缺陷综合征（MAIDS）中的免疫激活涉及一种超抗原（SAG）。通过使用Mtv小鼠，研究了乳腺肿瘤病毒（MTV）编码的SAGs可能作为刺激源的可能性。Mtv基因敲除小鼠患上了典型的MAIDS，排除了该疾病发病机制中对Mtv编码的SAGs的需求。

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本文引用的文献

1
Cells and cytokines in the pathogenesis of MAIDS, a retrovirus-induced immunodeficiency syndrome of mice.细胞与细胞因子在小鼠逆转录病毒诱导的免疫缺陷综合征（MAIDS）发病机制中的作用
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Evidence that the murine AIDS defective virus does not encode a superantigen.鼠类艾滋病缺陷病毒不编码超抗原的证据。
J Virol. 1996 Jan;70(1):1-9. doi: 10.1128/JVI.70.1.1-9.1996.
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Are there cellular superantigens?
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Positive selection of TcR alpha beta thymocytes: is cortical thymic epithelium an obligatory participant in the presentation of major histocompatibility complex protein?T细胞受体αβ胸腺细胞的阳性选择：皮质胸腺上皮细胞是主要组织相容性复合体蛋白呈递过程中的必需参与者吗？
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Allelotyping of butadiene-induced lung and mammary adenocarcinomas of B6C3F1 mice: frequent losses of heterozygosity in regions homologous to human tumor-suppressor genes.B6C3F1小鼠丁二烯诱导的肺癌和乳腺癌的等位基因分型：与人类肿瘤抑制基因同源区域杂合性的频繁缺失
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Preferential expansion and activation of V beta 5+ CD4+ T cells in murine acquired immunodeficiency syndrome.小鼠获得性免疫缺陷综合征中Vβ5 + CD4 + T细胞的优先扩增和激活。
J Immunol. 1993 Aug 1;151(3):1712-22.
8
Resistance to murine acquired immunodeficiency syndrome (MAIDS).对鼠类获得性免疫缺陷综合征（MAIDS）的抗性。
Science. 1994 Jul 8;265(5169):264-6; author reply 267. doi: 10.1126/science.8023146.
9
Murine AIDS is an antigen-driven disease: requirements for major histocompatibility complex class II expression and CD4+ T cells.鼠类艾滋病是一种抗原驱动性疾病：对主要组织相容性复合体II类表达和CD4+ T细胞的要求。
J Virol. 1994 Sep;68(9):5819-24. doi: 10.1128/JVI.68.9.5819-5824.1994.
10
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