p15gag和p12gag区域对于鼠艾滋病病毒的致病性而言都是必需的。
The p15gag and p12gag regions are both necessary for the pathogenicity of the murine AIDS virus.
作者信息
Kubo Y, Kakimi K, Higo K, Wang L, Kobayashi H, Kuribayashi K, Masuda T, Hirama T, Ishimoto A
机构信息
Department of Viral Oncology, Kyoto University, Japan.
出版信息
J Virol. 1994 Sep;68(9):5532-7. doi: 10.1128/JVI.68.9.5532-5537.1994.
The defective murine AIDS (MAIDS) virus has unique sequences in its p15gag and p12gag regions. To clarify whether these sequences are responsible for the development of MAIDS, we constructed recombinant viruses by replacing various regions of the gag gene of the nonpathogenic replication-competent LP-BM5 ecotropic virus with those of the MAIDS virus. Recombinants containing both unique sequences of the MAIDS virus were replication defective and induced MAIDS. However, a recombinant containing either the p15gag or p12gag region of the MAIDS virus was also replication defective but nonpathogenic in mice. A recombinant virus containing only the p30gag region of the MAIDS virus was replication competent and nonpathogenic. These results indicate that the p15gag and p12gag regions of the MAIDS virus do not function like those of replication-competent viruses and that both of the unique sequences in the p15gag and p12gag regions are required to develop MAIDS.
有缺陷的鼠类艾滋病（MAIDS）病毒在其p15gag和p12gag区域具有独特序列。为了阐明这些序列是否与MAIDS的发展有关，我们通过用MAIDS病毒的相应区域替换非致病性复制能力强的LP - BM5嗜亲性病毒的gag基因的各个区域，构建了重组病毒。含有MAIDS病毒两个独特序列的重组体复制有缺陷并引发了MAIDS。然而，含有MAIDS病毒p15gag或p12gag区域的重组体同样复制有缺陷，但在小鼠中无致病性。仅含有MAIDS病毒p30gag区域的重组病毒具有复制能力且无致病性。这些结果表明，MAIDS病毒的p15gag和p12gag区域的功能与复制能力强的病毒不同，并且p15gag和p12gag区域中的两个独特序列都是引发MAIDS所必需的。
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