Schaiberger P H, Kennedy T C, Miller F C, Gal J, Petty T L
Presbyterian/St. Lukes Medical Center, Denver.
Chest. 1993 Aug;104(2):614-6. doi: 10.1378/chest.104.2.614.
We present the case of a 33-year-old white male truck driver with a ten-year history of 3.5-g/wk "crank" and "peanut butter methamphetamine" inhalation (methamphetamine and propylhexedrine, respectively). This patient developed marked pulmonary hypertension as a probable consequence of abuse of these drugs. Proposed mechanisms of disease invoke toxic endothelial injury, hypoxic insult, direct spasm, vasculitis, and dysregulation of mediators of vascular tone. The possible role of genetics is discussed in reference to variability of human response to sympathomimetic challenge.
我们报告了一例33岁的白人男性卡车司机，有10年每周吸入3.5克“快克”和“花生酱甲基苯丙胺”（分别为甲基苯丙胺和丙己君）的病史。该患者因滥用这些药物可能导致了明显的肺动脉高压。提出的疾病机制包括毒性内皮损伤、缺氧损伤、直接痉挛、血管炎以及血管张力调节介质失调。结合人类对拟交感神经刺激反应的变异性，讨论了遗传学可能发挥的作用。
