University of South Florida, Department of Psychiatry and Neurosciences, 3515 E Fletcher Ave, MDC Box 14, Tampa, FL 33613, USA.
J Psychoactive Drugs. 2012 Jul-Aug;44(3):277-9. doi: 10.1080/02791072.2012.704593.
In 1949, propylhexedrine replaced amphetamine sulfate as the active ingredient in over the counter Benzedrex due to reports of widespread abuse, psychosis and sudden death. Since its introduction, cases of psychosis, myocardial infarction, pulmonary vascular disease, pulmonary hypertension, and sudden death attributed to propylhexedrine abuse have been well documented, usually in the form of single case reports. Although growing concerns during the 1980's regarding its abuse potential and its use as a precursor in the manufacture of compounds of even higher abuse potential caused propylhexedrine to be reviewed by the WHO Expert Committee on Drug Dependence, no formal studies of the dependence potential of propylhexedrine exists to date. The following is a case of propylhexedrine dependence, with some of its history, revisited.
1949 年，由于广泛滥用、精神病和猝死的报道，丙己君取代了安非他命硫酸盐成为非处方苯齐巨林的有效成分。自引入以来，丙己君滥用导致精神病、心肌梗死、肺血管疾病、肺动脉高压和猝死的病例已有充分记录，通常以单一病例报告的形式出现。尽管 20 世纪 80 年代对其滥用潜力及其作为制造更高滥用潜力化合物的前体的使用越来越关注，导致丙己君被世界卫生组织药物依赖专家委员会审查，但迄今为止，尚无关于丙己君依赖潜力的正式研究。以下是丙己君依赖的一个案例，其中包括一些历史回顾。
