Anderson R J, Garza H R, Garriott J C, Dimaio V
Am J Med. 1979 Jul;67(1):15-20. doi: 10.1016/0002-9343(79)90063-9.
Propylhexedrine was implicated in 15 deaths investigated by the Dallas County Medical Examiner since 1973. Twelve of the deaths were attributable to intravenous abuse of the contents of the Benzedrex® inhaler. Each death could be defined as sudden. Pulmonary edema, foreign body granulomas, fibrosis and evidence of pulmonary hypertension were frequent postmortem findings. Right ventricular hypertrophy was present in nine of the 12 subjects who died of intravenous propylhexedrine abuse. Two homicides and one suicide were propylhexedrine-related. Intravenous propylhexedrine abuse should be considered in the differential diagnosis of right ventricular hypertrophy and/or pulmonary hypertension, and it should be suspected in cases of sudden death involving young adults displaying evidence of intravenous drug abuse.
自1973年以来，丙己君与达拉斯县法医调查的15起死亡事件有关。其中12例死亡归因于静脉注射滥用苯齐德雷克斯吸入器的内容物。每例死亡均可定义为猝死。肺水肿、异物肉芽肿、纤维化和肺动脉高压证据是常见的尸检发现。在12例死于静脉注射丙己君滥用的受试者中，有9例出现右心室肥厚。两起凶杀案和一起自杀案与丙己君有关。在右心室肥厚和/或肺动脉高压的鉴别诊断中应考虑静脉注射丙己君滥用，在涉及有静脉药物滥用证据的年轻人猝死病例中应怀疑有此情况。
