Siegel A, Ohgami S, Edinger H
Brain Res. 1975 Dec 5;99(2):247-60. doi: 10.1016/0006-8993(75)90027-x.
An experiment was performed to determine the projections of the anterior, central, and posterior regions of hippocampus to the spetum in the squirrel monkey. Lesions were placed in each of these regions of hippocampus in 18 animals. Survival times varied from 5 to 7 days. Tissues were stained principally by the Fink-Heimer I method for identification of degenerating axons and their terminals. Following lesions which destroyed one or more fields of the anterior third of hippocampus degenerating axons were traced through the fimbria and fornix to the lateral septal area where dense quantities of terminal degeneration were observed. Smaller quantities of terminal degeneration were noted in the nucleus accumbens as well. After lesions of the middle third of hippocampus terminal degeneration was observed in an intermediolateral position within the septum. Following lesions of the posterior third of hippocampus degenerating terminals were observed in the area of the medial septum. All regions of hippocampus send fibers to the nucleus of the diagonal band and to the olfactory tubercle. These findings indicate that in the primate the projection to the septum from the hippocampus is topographically organized along its longitudinal axis in a manner that links the anterior hippocampus to the lateral septum and the posterior hippocampus to the medial septum.
进行了一项实验，以确定松鼠猴海马体的前区、中区和后区向隔区的投射。在18只动物的海马体这些区域分别进行损伤。存活时间从5天到7天不等。主要采用芬克 - 海默I法对组织进行染色，以识别退化的轴突及其终末。破坏海马体前三分之一一个或多个区域的损伤后，退化的轴突通过海马伞和穹窿追踪到外侧隔区，在那里观察到大量终末变性。伏隔核也观察到少量终末变性。海马体中间三分之一损伤后，在隔区内中间外侧位置观察到终末变性。海马体后三分之一损伤后，在内侧隔区观察到退化的终末。海马体的所有区域都向斜角带核和嗅结节发送纤维。这些发现表明，在灵长类动物中，海马体向隔区的投射沿其纵轴呈拓扑组织，以前海马体与外侧隔区相连、后海马体与内侧隔区相连的方式进行。
