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美沙酮治疗患者可卡因使用情况的描述性分析。

Descriptive analysis of cocaine use of methadone patients.

作者信息

Kidorf M, Stitzer M L

机构信息

Johns Hopkins University School of Medicine, Francis Scott Key Medical Center, Baltimore, MD 21224.

出版信息

Drug Alcohol Depend. 1993 May;32(3):267-75. doi: 10.1016/0376-8716(93)90091-4.

Abstract

The increasing prevalence of cocaine use among opioid-dependent participants in methadone treatment has been documented, but there is little information about the quantity-frequency aspects of use. This study examined the cocaine use of methadone maintenance patients to determine amounts and patterns of use as well as use in combination with other drugs. Forty-five cocaine using methadone maintenance patients (78% used i.v.) reported their drug use for each day over the past 7 days after receiving information about their most recent urinalysis test results. Average reported use was 0.23 g cocaine/day on 3.4 days/week. Heroin and cocaine were typically used simultaneously, while only a subset of patients (47%) who used alcohol drank within close proximity to cocaine. Patients who used cocaine with alcohol and/or heroin on the same day (N = 28) reported more cocaine use (M = 1.0 g/week) than patients who used cocaine alone (N = 17; M = 0.49 g/week). The results suggest that methadone maintenance patients generally engage in relatively low dose cocaine use, especially when compared to non opioid dependent patients applying to cocaine treatment programs. The study further shows that patients had clear preferences for drug use combinations, which suggests that interventions for cocaine use might focus on modifying drugs used in combination with cocaine.

摘要

美沙酮治疗中,阿片类药物依赖者使用可卡因的情况日益普遍,这一点已有记录,但关于使用量-频率方面的信息却很少。本研究调查了美沙酮维持治疗患者的可卡因使用情况,以确定使用量、使用模式以及与其他药物联合使用的情况。45名使用可卡因的美沙酮维持治疗患者(78%为静脉注射)在得知其最近一次尿液分析检测结果后,报告了过去7天中每天的药物使用情况。报告的平均使用量为每天0.23克可卡因,每周使用3.4天。海洛因和可卡因通常同时使用,而在使用酒精的患者中,只有一部分(47%)在接近使用可卡因的时间内饮酒。同一天使用可卡因和酒精及/或海洛因的患者(N = 28)报告的可卡因使用量(M = 1.0克/周)高于单独使用可卡因的患者(N = 17;M = 0.49克/周)。结果表明,美沙酮维持治疗患者通常使用相对低剂量的可卡因,尤其是与申请可卡因治疗项目的非阿片类药物依赖患者相比。该研究还表明,患者对药物联合使用有明确偏好,这表明针对可卡因使用的干预措施可能侧重于改变与可卡因联合使用的药物。

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