Dunshea F R
Department of Agriculture, Victorian Institute of Animal Science, Werribee, Australia.
J Anim Sci. 1993 Jul;71(7):1966-77. doi: 10.2527/1993.7171966x.
Porcine somatotropin (pST) and certain beta-adrenergic agonists are potent metabolic modifiers that can improve performance in pigs. Pigs treated with either compounds utilize feed more efficiently and are leaner than controls. Comparative slaughter data clearly demonstrate that pST and some beta-agonists stimulate protein deposition. Porcine somatotropin decreases lipid deposition, but this is not the case for all beta-agonists. Somatotropin decreases lipid deposition through decreasing adipose tissue sensitivity to insulin, inhibiting lipogenesis, and perhaps stimulating lipolysis. Although lipolysis is increased during pST treatment of growing pigs, the greatest consequence is decreased lipogenesis. Although under controlled conditions certain beta-agonists stimulate lipolysis and inhibit lipogenesis, the limited metabolic studies suggest that at doses that are most efficacious for enhanced protein deposition, there are limited effects on lipid metabolism. In part, this may be due to desensitization of adipose tissue beta-adrenergic receptors and possibly a consequence of antagonism of beta-receptors.
猪生长激素（pST）和某些β-肾上腺素能激动剂是强效的代谢调节剂，可改善猪的生产性能。用这两种化合物处理的猪比对照猪更有效地利用饲料，且更瘦。比较屠宰数据清楚地表明，pST和一些β-激动剂能刺激蛋白质沉积。猪生长激素可减少脂质沉积，但并非所有β-激动剂都如此。生长激素通过降低脂肪组织对胰岛素的敏感性、抑制脂肪生成以及可能刺激脂肪分解来减少脂质沉积。虽然在生长猪的pST处理期间脂肪分解增加，但最大的影响是脂肪生成减少。虽然在受控条件下某些β-激动剂刺激脂肪分解并抑制脂肪生成，但有限的代谢研究表明，在对增强蛋白质沉积最有效的剂量下，对脂质代谢的影响有限。部分原因可能是脂肪组织β-肾上腺素能受体脱敏，也可能是β-受体拮抗作用的结果。
