两种可在裸鼠中连续传代移植的新型人乳腺癌细胞系的建立及其特性
Establishment and characteristics of two new human mammary carcinoma lines serially transplantable in nude mice.
作者信息
Naundorf H, Fichtner I, Saul G J, Haensch W, Büttner B
机构信息
Max Delbrück Centre (MDC) for Molecular Medicine, Berlin-Buch, Germany.
出版信息
J Cancer Res Clin Oncol. 1993;119(11):652-6. doi: 10.1007/BF01215983.
Abstract
Two human mammary carcinomas of postmenopausal women were successfully transplanted into nude mice. Both tumours were classified as epidermal-growth-factor-, oestradiol- and progesterone-receptor-negative and c-erbB2-protein-positive. Histological studies of the primary tumours (4000 and 4151) revealed ductal invasive mammary carcinomas. In the first passages the precondition for the growth of breast carcinoma 4000 were pretreatments of the nude mice with oestradiol and peanut oil before transplantation. The mammary carcinomas 4000 and 4151 described here are suitable for in vivo testing of antineoplastic substances and for biological studies.
摘要
两名绝经后女性的人乳腺癌成功移植到裸鼠体内。两种肿瘤均被分类为表皮生长因子、雌二醇和孕酮受体阴性，c-erbB2蛋白阳性。对原发性肿瘤（4000和4151）的组织学研究显示为导管浸润性乳腺癌。在首次传代中，乳腺癌4000生长的前提条件是在移植前用雌二醇和花生油对裸鼠进行预处理。这里描述的乳腺癌4000和4151适用于抗肿瘤物质的体内测试和生物学研究。
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