Marx D, Schauer A, Reiche C, May A, Ummenhofer L, Reles A, Rauschecker H, Sauer R, Schumacher M
Pathologisches Institut, Universität Göttingen, Federal Republic of Germany.
J Cancer Res Clin Oncol. 1990;116(1):15-20. doi: 10.1007/BF01612634.
On the prognostic value of c-erbB2-encoded protein p185 in breast cancer there are controversal opinions. With the outlook of an evaluation of the prognostic value of p185 expression in breast cancer the relationships between p185 expression and known prognosis factors were investigated. Using polyclonal antibody against p185 33% out of 163 primary breast carcinomas are p185-positive. Within the various histological types of tumors the percentage of p185 expression differs. It is suggested that p185 indicates a certain type of biological behavior and plays a role in the pathogenesis of breast cancer. Thus the determination of p185 could allow definition of biological subclasses. A statistically significant correlation between expression of p185 and the presence of lymph node metastases or tumor size can not be proved. Nevertheless p185 expression is increased in cases with more than three positive lymph nodes. Expression of p185 correlates statistically significantly positively with histological grade and epidermal growth factor receptor, and negatively with steroid receptor status. Furthermore, high-proliferating tumors are more common in p185-positive cases than in p185-negative cases. It is concluded that p185 may be associated with an increased malignancy and proliferation activity of tumors.
关于c-erbB2编码蛋白p185在乳腺癌中的预后价值存在争议性观点。基于评估p185在乳腺癌中预后价值的前景，研究了p185表达与已知预后因素之间的关系。使用抗p185的多克隆抗体，163例原发性乳腺癌中有33%为p185阳性。在不同组织学类型的肿瘤中，p185表达的百分比有所不同。提示p185表明了某种生物学行为类型，并在乳腺癌的发病机制中起作用。因此，p185的测定可用于定义生物学亚类。无法证明p185表达与淋巴结转移或肿瘤大小之间存在统计学上的显著相关性。然而，在有三个以上阳性淋巴结的病例中，p185表达增加。p185表达与组织学分级和表皮生长因子受体在统计学上呈显著正相关，与类固醇受体状态呈负相关。此外，高增殖性肿瘤在p185阳性病例中比在p185阴性病例中更常见。结论是p185可能与肿瘤恶性程度和增殖活性增加有关。
