Naundorf H, Fichtner I, Büttner B, Frege J
Max-Delbrück-Centrum für Molekulare Medizin, Berlin-Buch, Federal Republic of Germany.
J Cancer Res Clin Oncol. 1992;119(1):35-40. doi: 10.1007/BF01209485.
A human mammary carcinoma originating from a postmenopausal patient was successfully transplanted into nude mice. According to the adopted criteria the tumour proved to be oestradiol- and progesterone-receptor-positive. Histological studies of the patient tumour revealed a ductal invasive mammary carcinoma with 80% tubular growth pattern. Following transplantation the adenoid structures decreased to 30%; the mitosis rate and grade of malignancy increased. Treatment of the nude mice with 20 micrograms oestradiol benzoate/mouse caused a loss of the oestradiol receptor of the mammary carcinoma. The mammary carcinoma 3366 can be used for testing of antineoplastic substances, antihormones and for studies in regard to down-regulation or blocking of hormone receptors and possible consequences for therapies.
一名绝经后患者的人乳腺癌成功移植到裸鼠体内。根据所采用的标准，该肿瘤被证明为雌二醇和孕酮受体阳性。对患者肿瘤的组织学研究显示为导管浸润性乳腺癌，管状生长模式占80%。移植后腺样结构减少到30%；有丝分裂率和恶性程度增加。用20微克苯甲酸雌二醇/只小鼠对裸鼠进行治疗导致乳腺癌的雌二醇受体丧失。乳腺癌3366可用于测试抗肿瘤物质、抗激素以及研究激素受体的下调或阻断及其对治疗可能产生的影响。
