Springfield D S
Orthopaedic Oncology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114.
Cancer Treat Res. 1993;67:81-98. doi: 10.1007/978-1-4615-3082-4_5.
It is clear that the alterations in wound healing caused by irradiation and chemotherapy are due to reduced rates of collagen production, probably from adverse effects of irradiation and chemotherapy on fibroblasts. The effect is to slow the process of wound healing so much that there is significantly more time for a complication to occur. If no complication occurs in the first 3-4 weeks after wound production, healing seems to proceed reasonably normally. The specific mechanisms by which irradiation and chemotherapy cause their damage is not known and additional research is needed.
很明显，放疗和化疗引起的伤口愈合改变是由于胶原蛋白生成速率降低，这可能是放疗和化疗对成纤维细胞产生不良影响所致。其结果是极大地延缓了伤口愈合过程，以至于出现并发症的时间显著增加。如果在伤口形成后的最初3 - 4周内没有发生并发症，愈合似乎会相当正常地进行。放疗和化疗造成损伤的具体机制尚不清楚，需要进一步研究。
