Yu J L, Wang L Q, Andersson R, Persson B G, Bengmark S
Department of Surgery, Lund University, Sweden.
Eur J Surg. 1993 Mar;159(3):163-6.
To develop a simple, reversible, reproducible model of obstructive jaundice in rats that could also be used for studies of infection associated with foreign bodies in the biliary tract.
Open study.
University of Lund, Sweden.
18 Male Sprague-Dawley rats.
Laparotomy and the placing of a "minioccluder" (developed in this laboratory) around the common bile duct. This was left in place for five days.
Results of standard liver function tests measured on days 0, 5, and 12; the degree of obstruction seen on cholangiography on day 12; and changes in body weight on days 5 and 12.
Activities of hepatic enzymes and plasma bilirubin concentrations were significantly increased on day 5 compared with day 0 (p < 0.01 in each case), but had returned to the reference range by day 12. Cholangiography (n = 10) showed that even though the part of the common bile duct proximal to the minioccluder was dilated the distal part was of normal diameter and patent. By 5 days the animals had lost 5% of their mean body weight, but this increased by 8% during the 7 days after relief of the occlusion (day 12).
We have developed a reversible, reproducible model of obstructive jaundice in rats, which can be used for the study of topics related to obstructive jaundice and in particular infection associated with foreign bodies in the biliary tract.
建立一种简单、可逆、可重复的大鼠梗阻性黄疸模型，该模型也可用于研究胆道异物相关感染。
开放性研究。
瑞典隆德大学。
18只雄性斯普拉格-道利大鼠。
剖腹手术并在胆总管周围放置一个“微型封堵器”（本实验室研制）。将其留置5天。
在第0天、第5天和第12天进行的标准肝功能测试结果；第12天胆管造影显示的梗阻程度；以及第5天和第12天体重的变化。
与第0天相比，第5天肝酶活性和血浆胆红素浓度显著升高（每种情况p<0.01），但到第12天已恢复至参考范围。胆管造影（n = 10）显示，尽管微型封堵器近端的胆总管部分扩张，但远端部分直径正常且通畅。到第5天时，动物平均体重减轻了5%，但在梗阻解除后的7天内（第12天）体重增加了8%。
我们建立了一种可逆、可重复的大鼠梗阻性黄疸模型，可用于研究与梗阻性黄疸相关的课题，特别是胆道异物相关感染。
