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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Tokyo Metropolitan Institute of Gerontology, Japan.

Comp Biochem Physiol Comp Physiol. 1993 Aug;105(4):653-8. doi: 10.1016/0300-9629(93)90264-5.

The mean and maximum life-spans of both wild type Caenorhabditis elegans and the mev-1(kn1) mutant, whose cytoplasmic superoxide dismutase activity level is about half of the wild type, were increased and decreased under low and high concentrations of oxygen, respectively. 2. The Gompertz component, a parameter of ageing rate, of the wild type was smaller under 1% oxygen than under 2% or more oxygen. Further, the Gompertz component of the mutant increased with an increase in oxygen concentration. 3. The oxygen-dependent modulation of life-span and ageing rate seems to be enhanced by a genetic defect of the mutant in antioxidant defence.

野生型秀丽隐杆线虫和mev-1(kn1)突变体（其细胞质超氧化物歧化酶活性水平约为野生型的一半）的平均寿命和最大寿命，分别在低氧和高氧浓度下增加和减少。2. 野生型衰老速率参数Gompertz成分在1%氧气条件下比在2%或更高氧气条件下小。此外，突变体的Gompertz成分随氧气浓度增加而增加。3. 突变体在抗氧化防御方面的遗传缺陷似乎增强了寿命和衰老速率的氧依赖性调节。

Tokyo Metropolitan Institute of Gerontology, Japan.

Comp Biochem Physiol Comp Physiol. 1993 Aug;105(4):653-8. doi: 10.1016/0300-9629(93)90264-5.

The mean and maximum life-spans of both wild type Caenorhabditis elegans and the mev-1(kn1) mutant, whose cytoplasmic superoxide dismutase activity level is about half of the wild type, were increased and decreased under low and high concentrations of oxygen, respectively. 2. The Gompertz component, a parameter of ageing rate, of the wild type was smaller under 1% oxygen than under 2% or more oxygen. Further, the Gompertz component of the mutant increased with an increase in oxygen concentration. 3. The oxygen-dependent modulation of life-span and ageing rate seems to be enhanced by a genetic defect of the mutant in antioxidant defence.

野生型秀丽隐杆线虫和mev-1(kn1)突变体（其细胞质超氧化物歧化酶活性水平约为野生型的一半）的平均寿命和最大寿命，分别在低氧和高氧浓度下增加和减少。2. 野生型衰老速率参数Gompertz成分在1%氧气条件下比在2%或更高氧气条件下小。此外，突变体的Gompertz成分随氧气浓度增加而增加。3. 突变体在抗氧化防御方面的遗传缺陷似乎增强了寿命和衰老速率的氧依赖性调节。