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[海马体单胺能和氨基酸能机制在不同起源焦虑状态中的作用及其参与抗焦虑药的抗厌恶作用]

[The role of monoamin- and acidergic mechanisms of the hippocampus in anxiety states of different origins and their participation in the antiaversive effects of anxiolytics].

作者信息

Talalaenko A N, Krivobok G K, Stakhovskiĭ Iu V

出版信息

Fiziol Zh Im I M Sechenova. 1993 Jan;79(1):99-104.

PMID:8100168
Abstract

The experiments on rats with tests of avoiding "lighting square" and "threatening situation" and with the chemical stimulation of dorsal and ventral hippocampus with dopamine, 5-HT, GABA and glutamine acid, showed different functional significance of these monoamines and acidergic transmitters agents in the states of anxiety of heteromodal aversive genesis. It seems that the variations in the action spectrum of anxiolytics under study are due to unequal degree of 5-HT and GABA-ergic transmitter mechanisms of dorsal and ventral hippocampus.

摘要

对大鼠进行了避免“光照方格”和“威胁情境”测试，并通过多巴胺、5-羟色胺、γ-氨基丁酸和谷氨酸对背侧和腹侧海马体进行化学刺激的实验，结果表明这些单胺类和酸性递质在异模态厌恶源焦虑状态中具有不同的功能意义。似乎所研究的抗焦虑药作用谱的变化是由于背侧和腹侧海马体中5-羟色胺和γ-氨基丁酸能递质机制的程度不同所致。

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