Johnson M, Bush L G, Hanson G R, Gibb J W
Department of Pharmacology and Toxicology, University of Utah, Salt Lake City 84112.
Biochem Pharmacol. 1993 Aug 17;46(4):770-2. doi: 10.1016/0006-2952(93)90568-h.
The concentration of serotonin (5-HT) measured in rat striatum was reduced to 75% of control 1 week after a single subcutaneous administration of dl-3,4-methylenedioxymethamphetamine (MDMA, 20 mg/kg). This decrease was prevented by pretreating the animals with ritanserin. Eighteen hours after MDMA (20 mg/kg), striatal concentrations of neurotensin-like immunoreactivity (NTLI) and of dynorphin A-like immunoreactivity (DLI) were increased to 250 and 487% of control, respectively, but ritanserin failed to prevent these changes. This study supports a role for 5-HT2 receptors in the mechanism by which a single high dose of MDMA induces neuronal damage to the serotonergic system, but not the MDMA-induced increase in central NTLI and DLI concentrations.
单次皮下注射dl - 3,4 - 亚甲基二氧甲基苯丙胺（摇头丸，20毫克/千克）1周后，大鼠纹状体中测得的血清素（5 - HT）浓度降至对照组的75%。用利坦色林预处理动物可防止这种降低。给予摇头丸（20毫克/千克）18小时后，纹状体中神经降压素样免疫反应性（NTLI）和强啡肽A样免疫反应性（DLI）浓度分别增加至对照组的250%和487%，但利坦色林未能阻止这些变化。本研究支持5 - HT2受体在单次高剂量摇头丸诱导血清素能系统神经元损伤的机制中起作用，但不支持其在摇头丸诱导的中枢NTLI和DLI浓度增加中的作用。
