甲基苯丙胺对纹状体-黑质强啡肽系统影响的特征分析。

Characterization of methamphetamine effects on the striatal-nigral dynorphin system.

作者信息

Hanson G R, Merchant K M, Letter A A, Bush L, Gibb J W

机构信息

Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City 84112.

出版信息

Eur J Pharmacol. 1988 Oct 11;155(1-2):11-8. doi: 10.1016/0014-2999(88)90397-4.

DOI:10.1016/0014-2999(88)90397-4

PMID:2907484

Abstract

Multiple high doses of methamphetamine (METH) induced 200-300% increases in the concentration of striatal and nigral dynorphin-like immunoreactivity (DLI). Increases in striatal and nigral DLI levels also were seen within 6 h following a single administration. The changes in the striatal-nigral dynorphin system had subsided 48 h after either acute or multiple treatments with METH. Selective lesioning of the nigral-striatal dopamine pathway blocked the effects; thus, the METH-induced changes appeared to be mediated by dopamine released from the nigral-striatal dopamine projection. Administration of the METH analog, 3,4-methylenedioxymethamphetamine, appeared to alter striatal and nigral DLI concentrations in a manner similar to that of METH.

摘要

多次高剂量甲基苯丙胺（METH）致使纹状体和黑质中强啡肽样免疫反应性（DLI）浓度增加200 - 300%。单次给药后6小时内，纹状体和黑质中的DLI水平也有所升高。无论是急性还是多次给予METH后，纹状体 - 黑质强啡肽系统的变化在48小时后消退。黑质 - 纹状体多巴胺通路的选择性损伤阻断了这些效应；因此，METH诱导的变化似乎是由黑质 - 纹状体多巴胺投射释放的多巴胺介导的。给予METH类似物3,4 - 亚甲基二氧基甲基苯丙胺似乎以与METH类似的方式改变纹状体和黑质中的DLI浓度。