刚果红对瘙痒病病原体复制的抑制作用
Congo red inhibition of scrapie agent replication.
作者信息
Caughey B, Ernst D, Race R E
机构信息
Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840.
出版信息
J Virol. 1993 Oct;67(10):6270-2. doi: 10.1128/JVI.67.10.6270-6272.1993.
Congo red inhibits the accumulation of protease-resistant PrP in scrapie-infected mouse neuroblastoma cells. Here we show that Congo red also inhibits the replication of scrapie infectivity in these cells. This observation is consistent with the idea that protease-resistant PrP is a vital component of the scrapie agent or that agent replication depends on the presence of protease-resistant PrP in the cell.
刚果红可抑制瘙痒病感染的小鼠神经母细胞瘤细胞中抗蛋白酶的朊蛋白（PrP）的积累。在此我们表明，刚果红还可抑制这些细胞中瘙痒病感染性的复制。这一观察结果与以下观点一致，即抗蛋白酶的PrP是瘙痒病病原体的重要组成部分，或者病原体的复制依赖于细胞中抗蛋白酶的PrP的存在。
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