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睡眠期周期性运动(夜间肌阵挛)患者的多巴胺D2受体改变。

Dopamine D2 receptor alteration in patients with periodic movements in sleep (nocturnal myoclonus).

作者信息

Staedt J, Stoppe G, Kögler A, Munz D, Riemann H, Emrich D, Rüther E

机构信息

Department of Psychiatry, Georg August University, Göttingen, Federal Republic of Germany.

出版信息

J Neural Transm Gen Sect. 1993;93(1):71-4. doi: 10.1007/BF01244940.

Abstract

Periodic movements in sleep (PMS) can cause severe sleep disturbances. We investigated the central dopamine D2 receptor density in patients with PMS with 123I-IBZM and single photon emission tomography (SPET). In PMS there was a lower 123I-IBZM binding in the basal ganglia compared to the control group. The results indicate a loss of central D2 receptors in PMS.

摘要

睡眠期周期性运动(PMS)可导致严重的睡眠障碍。我们使用123I-碘苄胍(123I-IBZM)和单光子发射断层扫描(SPET)研究了PMS患者中枢多巴胺D2受体密度。与对照组相比,PMS患者基底节区的123I-IBZM结合较低。结果表明PMS患者存在中枢D2受体缺失。

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