Orisakwe O E, Obi N
Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Anambra State.
Hum Exp Toxicol. 1993 Jul;12(4):301-3. doi: 10.1177/096032719301200408.
The in vitro and in vivo adsorption of diazinon to two brands of activated charcoal and locally produced carbon black (N220) has been studied. Solutions of diazinon 10, 20 and 40 micrograms ml-1 were prepared in distilled water and different quantities of adsorbent added. Diazinon-adsorbent slurries were vortex mixed, centrifuged and analysed for free diazinon spectrophotometrically at 241 nm. Small quantities of activated charcoal (AC) and carbon black (CB) showed little or no adsorption of diazinon, while 1000 mg of either AC or CB was able to take up more than 70% at all concentrations of diazinon tested. In acute toxicity tests in mice the optimal adsorbent: diazinon ratio was 8:1 when the animals were treated with 45 mg kg-1 diazinon after immediate, 1, and 3 h post administration of the adsorbent.
已研究了二嗪农在两种品牌活性炭和本地生产的炭黑（N220）上的体外和体内吸附情况。在蒸馏水中制备了浓度为10、20和40微克/毫升的二嗪农溶液，并添加了不同量的吸附剂。将二嗪农-吸附剂浆液进行涡旋混合、离心，然后在241纳米处用分光光度法分析游离二嗪农。少量的活性炭（AC）和炭黑（CB）对二嗪农的吸附很少或没有吸附，而1000毫克的AC或CB在所有测试的二嗪农浓度下都能吸附70%以上。在小鼠急性毒性试验中，当在给予吸附剂后立即、1小时和3小时用45毫克/千克二嗪农处理动物时，最佳吸附剂与二嗪农的比例为8:1。
