Orisakwe O E, Ofoefule S I, Dioka C E, Ufearo C S, Nwobodo E O
Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Anambra State, Nigeria.
Tokai J Exp Clin Med. 1995 Jul;20(2):67-70.
The adsorptive capacities of locally produced carbon black (N220) and activated charcoal in the management of poisoning due to some locally used drugs were investigated. Adsorption of metronidazole and tinidazole to carbon black (CB) and activated charcoal (AC) was completed within 30 min of incubation and was found to be dependent on the quantities used CB-B50 for metronidazole and tinidazole were 132.7 and 112.2 mg while AC-B50 for the two drugs were 254.7 and 125.9 mg, respectively. In the in-vivo study, 20 mg/kg of chloroquine given orally, then followed with 1.6 g/kg of either CB or AC by the same route, gave optimal protection against death in mice. The mortality rate decreased as the amount of adsorbents increased. We suggest that carbon black may be beneficial when properly handled and adequately administered during overdosage or accidental poisoning by metronidazole, tinidazole, or chloroquine.
研究了本地生产的炭黑（N220）和活性炭对一些本地使用药物中毒的吸附能力。甲硝唑和替硝唑在孵育30分钟内完成对炭黑（CB）和活性炭（AC）的吸附，且发现其依赖于所使用的量，甲硝唑和替硝唑的CB - B50分别为132.7和112.2毫克，而两种药物的AC - B50分别为254.7和125.9毫克。在体内研究中，口服给予20毫克/千克氯喹，然后通过相同途径给予1.6克/千克的CB或AC，可对小鼠死亡提供最佳保护。死亡率随着吸附剂用量的增加而降低。我们建议，在甲硝唑、替硝唑或氯喹过量或意外中毒时，若处理得当且给药充分，炭黑可能有益。
